Guanidine Thiocyanate CAS 593-84-0
Factory wholesale Guanidine Thiocyanate CAS 593-84-0
- Appearance:Liquid
- Purity:99.8%
- Delivery:30days
- Sample Available:Available
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Name: Guanidine Thiocyanate
CAS: 593-84-0
MOQ: 1KG
Directory Guidance on Guanidine Thiocyanate
Chemical Structure
Basic Info:
| Melting Point | 120-122 °C(lit.) |
| Bulk Density | 630kg/m3 |
| Density | 1.103 g/mL at 20 °C |
| Vapor Pressure | 0Pa at 20℃ |
| Refractive Index | n20/D 1.482 |
Guanidine Thiocyanate Introduction:
Guanidine Thiocyanate is an ionic compound formed by the combination of guanidine cation and thiocyanate anion, with the chemical formula C(NH₂)₃⁺·SCN⁻. In its molecular structure, the guanidine part is composed of three amino groups surrounding a central carbon atom, which gives the molecule strong alkalinity; thiocyanate has high polarity and can form coordination compounds with a variety of metal ions.
In terms of physical properties, Guanidine Thiocyanate usually appears as a white to off-white crystalline powder, which is easily soluble in polar solvents such as water and ethanol, and slightly soluble in non-polar solvents. Its aqueous solution is neutral to weakly alkaline, the pH value is less affected by concentration and temperature, the chemical stability is high, and it is not easy to decompose at room temperature.
Under high temperature or strong acid and strong base conditions, it may undergo hydrolysis or oxidation reactions to produce by-products such as urea and sulfide. Therefore, in practical applications, the reaction conditions must be strictly controlled to avoid side reactions.
The industrial production of this product is mainly achieved through the double decomposition reaction of guanidine salt and thiocyanate. Taking guanidine hydrochloride and sodium thiocyanate as an example, the two undergo ion exchange reaction in aqueous solution to generate Guanidine Thiocyanate precipitation, which is then centrifuged, washed and dried to obtain a high-purity product.
This process has low requirements for equipment, but the reaction time, temperature and material ratio must be precisely controlled to ensure product yield and purity. In recent years, with the improvement of environmental protection requirements, some companies have begun to use membrane separation technology to replace traditional crystallization processes to further reduce energy consumption and wastewater discharge.
As a common laboratory reagent, Guanidine Thiocyanate should be stored away from light, moisture, and strong oxidants and acidic substances. Its solid form can be stored for a long time in a dry environment, but its solution state is susceptible to microbial contamination. It is recommended to prepare it for use or add preservatives.
During transportation, it is necessary to comply with the management regulations for hazardous chemicals to avoid direct contact with the skin or inhalation of dust. Although its acute toxicity is low, long-term exposure may cause irritation to the respiratory tract and mucous membranes, and protective equipment must be worn during operation.
Nature and Specifications:
| Item | Specification |
| Product Name | Guanidine Thiocyanate |
| CAS No. | 593-84-0 |
| Appearance | Powder |
| Shelf Life | 2 years |
| Packing | As Your Requirements |
| Form | Crystals or Crystalline Powder |
| Color | White or colorless |
| Specific Gravity | 1.152 |
| Odor | Odorless |
Product service:
- Certificate Of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Route of synthesis (ROS)
- Method of Aanlysis (MOA)
- Nuclear Magnetic Resonance (NMR)
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- Free Sample
- Factory audit
The Application of Guanidine Thiocyanate
Guanidine Thiocyanate has long been utilized as an efficient solvent in nucleic acid extraction experiments due to its strong chaotropic sequence characteristics. Guanidine’s strong chaotropic sequence allows it to disrupt cell membrane structures, release DNA and RNA and inhibit nucleases by competitively binding water molecules thereby protecting nucleic acids from degradation.
Under high concentration conditions, it can bind with silica gel membranes or magnetic microspheres for efficient adsorption and purification of nucleic acids – making it one of the essential reagents in technologies like molecular diagnosis and gene sequencing.
Guanidine Thiocyanate is frequently employed in molecular biology research for protecting and stabilizing RNA. When cell lysis takes place, Guanidine Thiocyanate quickly inactivates any enzymes responsible for breaking down RNA while protecting its integrity; making it particularly suitable for sample processing of tissues with high RNase content like livers and pancreases.
Combine with b-mercaptoethanol for maximum protein denaturation effect; and it is often employed as part of sample pretreatment for Western blot experiments. In recent years, its application in single cell sequencing has increased. By tailoring its formula optimally, simultaneous cell lysis and nucleic acid stabilization can be accomplished in microliter-scale reaction systems.
Guanidine Thiocyanate stands out in industrial catalysis as an exceptional phase transfer catalyst. The thiocyanate’s unique molecular composition allows it to effectively complex metal ions, reduce activation energy for reactions such as esterification and alkylation, as well as accelerate organic synthesis processes more quickly than any other catalyst available.
Polyurethane production utilizes this substance as a foaming catalyst to control pore size distribution of foam by altering reaction rate, improving mechanical properties of material, and controlling its pore size distribution. Furthermore, fine chemical production often uses it as chiral inducer to increase optically active products’ enantiomeric excess.
Guanidine Thiocyanate has long been used in materials science as a functional polymer material additive, through covalent or ionic bonds to the polymer matrix skeleton, to dramatically enhance surface properties such as hygroscopicity and antibacterial protection of materials.
Guanidine Thiocyanate can be an invaluable morphology control agent when synthesizing nanomaterials, serving to regulate both size and shape of metal oxide nanoparticles. For instance, during hydrothermal synthesis of zinc oxide nanorods using hydrothermal methods, appropriate addition of Guanidine Thiocyanate will inhibit axial growth to create short rod-like structures with high specific surface area.
Guanidine Thiocyanate is widely utilized in the pharmaceutical industry as an intermediate in the synthesis of antibacterial and antiviral drugs, acting as a donor guanidine to contribute to building active center structures of drug molecules.
Guanidine Thiocyanate can be used in pharmaceutical preparations by combining it with inclusion materials like cyclodextrin to increase bioavailability of poorly soluble drugs, or with sustained-release formulations to achieve long-term therapeutic effects by controlling drug release rates.
The Advantages of Guanidine Thiocyanate:
Guanidine Thiocyanate’s greatest advantage lies in its versatility: one single molecule simultaneously possesses strong out-of-liquid sequentiality, metal complexation ability and chemical stability – qualities which enable it to meet multiple application needs in various scenarios. When compared with traditional denaturants like sodium dodecyl sulfate (SDS), its denaturing effect on biological macromolecules is milder; breaking non-covalent bonds without nucleic acid cleavage makes this ideal for experiments where maintaining biomolecule integrity is key, like extracting full-length RNA or purifying natural proteins from natural sources.
Guanidine Thiocyanate offers significant time savings when it comes to reaction efficiency, such as nucleic acid extraction. For example, cell lysis and nuclease inactivation can be completed within minutes instead of taking over 30 minutes with traditional methods like phenol-chloroform. Furthermore, industrial production benefits greatly from its catalytic activity which reduces reaction cycles while cutting energy usage; when added 0.1%-0.5% Guanidine Thiocyanate can shorten reaction cycles by 20%-30% while significantly improving production efficiency – such as polyurethane foaming process where adding 0.1%-0.5% Guanidine Thiocyanate can shorten reaction cycles by as much as 25%-30%!
Chemical stability makes Guanidine Thiocyanate an exceptional storage product. Solid forms can remain stored safely at room temperature for over three years, and solution state remains active within a pH range of 5-9 for over twelve months – these long shelf life features minimize transportation and storage costs and make this material particularly suitable for industrial users who must keep stocks for long.
Guanidine Thiocyanate production process is highly economic and its raw materials readily available, with Guanidine hydrochloride and sodium thiocyanate being its two main constituents, both available with small price fluctuations and abundant market supply. With continuous production technology’s introduction, unit production costs have decreased approximately 15% since 2011 while price competitiveness has further been strengthened. Furthermore, due to reusable features of this chemical such as reduced wastewater treatment costs in fields like electroplating it provides significant comprehensive advantages.
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Related References:
Chemicalbook-Guanidine Thiocyanate
Guanidine Thiocyanate Manufacturer
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